Mathias Leinders

Department of Neurology,
University of Würzburg
Josef-Schneider-Str. 11
97080 Würzburg

Department:

Department of Neurology, University of Würzburg

Project:

Title: microRNAs (miRNAs) and their role in painful vs. non-painful polyneuropathies.
Abstract: microRNAs (miRNAs) post-transcriptionally regulate gene expression and have been implicated as biomarkers for a wide range of diseases, including cancer, inflammation and neurological diseases. This projects aims to investigate whether miRNAs are clinically relevant for the induction and maintenance of pain and moreover involved in regulations of pain-like sensations in higher brain centers, pre-clinically.

Principal investigator:

Prof. Dr. C. Sommer
Prof. Dr. U. Fischer
Prof. Dr. K.-P. Lesch
PD Dr. A. Schmitt

Related projects/members:

Prof. Dr. Ronald Deumens (collaboration)
https://www.uclouvain.be/en-276857.html

Previous studies:

B.Sc. Molecular Biomedicine Maastricht University

M.Sc. University of California, San Diego

Master Thesis:

Expression and functional relevance of spinal phosphoinositide 3-Kinases in carrageenan-induced pain behavior

Publications:

Andrade P, Visser-Vandewalle V, Leinders M, Daemen M, Steinbusch HW, Buurman WA, Hoogland G: Inflammation and chronic pain: correlation between inflammatory profiles and pain evaluation in humans. (submitted EJP)

Leinders M, F. Koehrn, G. S. Firestein, L. Sorkin: Expression and functional relevance of spinal phosphoinositide 3-Kinases in carrageenan-induced pain behavior. (submitted pain).

Leinders M, Knaepen L, Emmanuel Hermans, Marc  De Kock, Sommer C Deumens R: Microglial responses to nerve injury persistent also after resolution of pain hypersensitivity (manuscript in preparation).

Leinders M, Knaepen L, De Kock M, Sommer C, Hermans E, Deumens R. (2013).Up-regulation of spinal microglia Iba-1 expression persists after resolution of neuropathic pain hypersensitivity. http://www.ncbi.nlm.nih.gov/pubmed/?term=Leinders+M%5BAuthor%5D#Neurosci Lett. 2013 Sep 8. pii: S0304-3940(13)00795-7. doi: 10.1016/j.neulet.2013.08.062.

M. Leinders, F. Koehrn, B. Bartok, G. S. Firestein, L. Sorkin (2012). 14th World Congress on Pain (IASP), Milan (IT). Expression and functional relevance of spinal phosphoinositide 3-Kinases in carrageenan-induced pain behavior.

L. Sorkin, M. Leinders, F. Koehrn (2012). The Society for Neuroscience (SFN) 42nd Annual Meeting, New Orleans (US). Expression and functional relevance of spinal phosphoinositide 3-Kinases in carrageenan-induced pain behavior.